Tatiana started her scientific career in the laboratory of Dr. Juan Botas at Baylor college of medicine, Houston (Texas) in 2011 as a research assistant, working with Drosophila as an animal model of neurodegenerative diseases.  She completed her PhD in neuroscience working on an evolutionary perspective of the vertebrate nervous system using the lizard Pogona vitticeps as an animal model in the group of Dr. Gilles Laurent at the MPI for Brain research (Frankfurt).

Since 2022 she is part of Garcia-Moreno‘s group where she develops her career as a postdoc.

Publications:

Hain D*, Gallego-Flores T*, Klinkmann M, Macias A, Ciirdaeva E, Arends A, Thum C, Tushev G, Kretschmer F, ToschesMA and Laurent G (2022) – “Molecular diversity and evolution of neuron types in the amniote brain” – Science, accepted for publication July 2022. Asterisks denote equal contribution. 

Norimoto H, Fenk LA, Li HH, Tosches MA, Gallego-Flores T, Hain D, Reiter S, Kobayashi R, Macias A, Arends A, Klinkmann M, Laurent G. A claustrum in reptiles and its role in slow-wave sleep. Nature. 2020 Feb;578(7795):413-418. doi: 10.1038/s41586-020-1993-6. Epub 2020 Feb 12. PMID: 32051589.

Sarrion-Perdigones A, Chang L, Gonzalez Y, Gallego-Flores T, Young DW, Venken KJT. Examining multiple cellular pathways at once using multiplex hextuple luciferase assaying. Nat Commun. 2019 Dec 13;10(1):5710. doi: 10.1038/s41467-019-13651-y. PMID: 31836712; PMCID: PMC6911020.

Huichalaf CH, Al-Ramahi I, Park KW, Grunke SD, Lu N, de Haro M, El-Zein K, Gallego-Flores T, Perez AM, Jung SY, Botas J, Zoghbi HY, Jankowsky JL. Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer’s disease. Hum Mol Genet. 2019 Jun 15;28(12):2014-2029. doi: 10.1093/hmg/ddz034. PMID: 30753434; PMCID: PMC6548227.

Al-Ramahi I, Lu B, Di Paola S, Pang K, de Haro M, Peluso I, Gallego-Flores T, Malik NT, Erikson K, Bleiberg BA, Avalos M, Fan G, Rivers LE, Laitman AM, Diaz-García JR, Hild M, Palacino J, Liu Z, Medina DL, Botas J. High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration. Cell Syst. 2018 Jul 25;7(1):28-40.e4. doi: 10.1016/j.cels.2018.05.010. Epub 2018 Jun 20. PMID: 29936182; PMCID: PMC6082401.

Park J, Al-Ramahi I, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Lu HC, Lagalwar S, Duvick L, Kang H, Lee Y, Jafar-Nejad P, Sayegh LS, Richman R, Liu X, Gao Y, Shaw CA, Arthur JSC, Orr HT, Westbrook TF, Botas J, Zoghbi HY. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 2013 Jun 20;498(7454):325-331. doi: 10.1038/nature12204. Epub 2013 May 29. PMID: 23719381; PMCID: PMC4020154.

Lu B, Al-Ramahi I, Valencia A, Wang Q, Berenshteyn F, Yang H, Gallego-Flores T, Ichcho S, Lacoste A, Hild M, Difiglia M, Botas J, Palacino J. Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance. Nat Neurosci. 2013 May;16(5):562-70. doi: 10.1038/nn.3367. Epub 2013 Mar 24. PMID: 23525043.