IGF-I is a crucial hormone with pleiotropic effects on growth, metabolism, and neuroplasticity. Emerging evidence suggests that IGF-I also plays a key role in modulating behavior and lifestyle choices, including physical activity, dietary preferences, stress responses, and social interactions. This seminar will explore how IGF-I influences neural circuits involved in emotion, reward, and social interaction. We will analyze experimental studies linking IGF-I levels with variations in lifestyle-related behaviors, such as exercise adherence, social interaction, and sleep regulation. Understanding the behavioral role of IGF-I may offer new insights for interventions in lifestyle-related diseases and mental health disorders.