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Amaia Arranz Mendiguren

Principal Investigator

Ramón y Cajal Fellow, Ikerbasque Research Associate

Amaia Arranz Mendiguren

Research groups:

Contact

Email:Amaia.Arranz@achucarro.org

Tel.:(+34) 94 601 8355

Science Park of the UPV/EHU
Sede Building, 3rd floor, Barrio Sarriena, s/n
E-48940 Leioa Spain

0000-0002-8314-7870

About me

I am currently a Ramon y Cajal and Ikerbasque Research Associate leading the Laboratory of Humanized Models of Disease. 

Our lab aims at unraveling human astrocyte-specific pathways and mechanisms involved in the pathogenesis and progression of Alzheimer’s disease. Our approaches include the use of humanized in vitro models, chimeric mice and postmortem samples from Alzheimer’s disease patients that allow exploration of human astrocytes at morphological, molecular, biochemical and functional levels.

Publications

  1. APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
    Preman, Pranav; Moechars, Daan; Fertan, Emre; Wolfs, Leen; Serneels, Lutgarde; Shah, Disha; Lamote, Jochen; Poovathingal, Suresh; Snellinx, An; Mancuso, Renzo; Balusu, Sriram; Klenerman, David; Arranz, Amaia M; Fiers, Mark; De Strooper, Bart
    EMBO Molecular Medicine (Nov, 2024) DOI: 10.1038/s44321-024-00162-7

  2. Centenarian hippocampus displays high levels of astrocytic metallothioneins
    Saenz-Antoñanzas, Ander; Muñoz-Culla, Maider; Rigo, Piero; Ruiz-Barreiro, Leire; (...), ; Arranz Mendiguren, Amaia; Otaegui, David; Guillemot, François; Matheu, Ander
    Aging Cell (May, 2024) DOI: 10.1111/acel.14201

  3. A neuron-specific interaction between Alzheimer’s disease risk factors SORL1, APOE, and CLU
    Preman, Pranav; Arranz, Amaia M.
    Cell Reports (Sep, 2023) DOI: 10.1016/j.celrep.2023.113129

  4. MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
    Balusu, Sriram; Horré, Katrien; Thrupp, Nicola; Craessaerts, Katleen; Snellinx, An; Serneels, Lutgarde; T’Syen, Dries; Chrysidou, Iordana; Arranz Mendiguren, Amaia; (...), ; Fiers, Mark; De Strooper, Bart
    Science (Sep, 2023) DOI: 10.1126/science.abp9556

  5. hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer’s disease and potential therapeutics
    TCW, Julia; Arranz, Amaia M.
    Molecular Neurodegeneration (Mar, 2023) DOI: 10.1186/s13024-023-00612-9

  6. Evolution of neuroglia
    Verkhratsky, Alexei; Arranz, Amaia M.; Ciuba, Katarzyna; Pękowska, Aleksandra
    Annals of the New York Academy of Sciences (Dec, 2022) DOI: 10.1111/nyas.14917

  7. Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques
    Preman, Pranav; TCW, Julia; Calafate, Sara; Snellinx, An; Alfonso-Triguero, Maria; Corthout, Nikky; Munck, Sebastian; Thal, Dietmar Rudolf; Goate, Alison M.; De Strooper, Bart; Arranz, Amaia M.
    Molecular Neurodegeneration (Sep, 2021) DOI: 10.1186/s13024-021-00487-8

  8. Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways
    Preman, Pranav; Alfonso-Triguero, Maria; Alberdi, Elena; Verkhratsky, Alexei; Arranz, Amaia M.
    Cells (Mar, 2021) DOI: 10.3390/cells10030540
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