Unveiled the developmental origin of adult hippocampal neural stem cells
10
Jan
2024
Researchers from ACHUCARRO, Oier Pastor-Alonso, Fernando García-Moreno, Soraya Martín-Suárez, and Juan Manuel Encinas have collaborated with Anja Urbach and her group at the Jena University Hospital in Germany to unveil the developmental origin of adult hippocampal neural stem cells.
In an article published in The EMBO Journal, the researchers used transgenic mice, retroviral vectors, and imaging to show that adult hippocampal neural stem cells are generated on-site postnatally in a cyclin D2-dependent manner. This work solves one of the major questions in the field of adult neurogenesis and challenges the prevalent notion in the field of adult hippocampal neurogenesis as being a continuum of developmental neurogenesis.