Targeting Mitochondria-ER Contacts: A New Perspective on Treating Neurodegenerative Diseases

Mitochondria-ER contacts (MERCS) are emerging as key players in cellular health, influencing critical processes like calcium signaling, lipid transfer, and mitophagy. At ACHUCARRO, we are investigating how the BCL-2 protein family, traditionally known for regulating cell death, impacts MERCS dynamics and how their dysfunction might drive diseases like Alzheimer’s, Parkinson’s, and cancer.

Our research highlights the potential of MERCS as both a sensor and regulator of disease progression, linking their disruption to early stages of neurodegeneration. By exploring how BCL-2 proteins influence these interactions, we aim to uncover new therapeutic opportunities that could improve mitochondrial-ER communication and offer novel treatments for these widespread disorders.