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Amanda Sierra Saavedra

Principal Investigator

Ikerbasque Research Professor

Amanda Sierra Saavedra

Research groups:

Contact

Email:Amanda.Sierra@achucarro.org

Tel.:(+34) 94 601 8136

Science Park of the UPV/EHU
Sede Building, 3rd floor, Barrio Sarriena, s/n
E-48940 Leioa Spain

0000-0001-8415-096X

About me

PhD Universidad Complutense de Madrid, 2003

Our laboratory works on the study of microglial cells at the interplay between phagocytosis and inflammation in the diseased brain. The research involves the study of the cellular and molecular mechanisms involved in the regulation of the efficiency of microglial phagocytosis.

Publications

  1. A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors
    Rodriguez-Iglesias, N.; Paris, I.; Valero, J.; Cañas-Zabala, L.; Carretero, A.; Hatje, K.; Zhang, J.D.; Patsch, C.; Britschgi, M.; Gutbier, S.; Sierra, A.
    GLIA (Oct, 2024) DOI: 10.1002/glia.24637

  2. Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)
    Sierra, Amanda; Miron, Veronique E.; Paolicelli, Rosa C.; Ransohoff, Richard M.
    Cold Spring Harbor Perspectives in Biology (Aug, 2024) DOI: 10.1101/cshperspect.a041366

  3. Interferons: Invited guests at the brain’s gala banquet
    Márquez-Ropero, Mar; Sierra, Amanda
    Neuron (Apr, 2024) DOI: 10.1016/j.neuron.2024.03.010

  4. Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis
    Montilla, Alejandro; Zabala, Alazne; Er-Lukowiak, Marco; Rissiek, Björn; Magnus, Tim; Rodriguez-Iglesias, Noelia; Sierra, Amanda; Matute, Carlos; Domercq, María
    Cell Death & Disease (Jan, 2023) DOI: 10.1038/s41419-023-05551-3

  5. Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy
    Beccari, Sol; Sierra-Torre, Virginia; [...] Plaza-Zabala, Ainhoa; Sierra, Amanda
    Autophagy (Jan, 2023) DOI: 10.1080/15548627.2023.2165313

  6. Microglia states and nomenclature: A field at its crossroads
    Paolicelli, Rosa C.; Sierra, Amanda; [...] Wu, Long-Jun; Wyss-Coray, Tony
    Neuron (Nov, 2022) DOI: 10.1016/j.neuron.2022.10.020

  7. Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia
    Rodríguez-Iglesias, Noelia; Nadjar, Agnes; Sierra, Amanda; Valero, Jorge
    International Journal of Molecular Sciences (Mar, 2022) DOI: 10.3390/ijms23063399

  8. Editorial: Assessing Microglial Function and Identity
    Sierra, Amanda; Paolicelli, Rosa Chiara
    Frontiers in Immunology (Dec, 2021) DOI: 10.3389/fimmu.2021.824866

  9. Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain
    Askew, K.; Li, K.; Olmos-Alonso, A.; Garcia-Moreno, F.; Liang, Y.; Richardson, P.; Tipton, T.; Chapman, M.A.; Riecken, K.; Beccari, S.; Sierra, A.; Molnár, Z.; Cragg, M.S.; Garaschuk, O.; Perry, V.H.; Gomez-Nicola, D.
    Cell Reports (Jan, 2017) DOI: 10.1016/j.celrep.2016.12.041

  10. Neuronal Hyperactivity Accelerates Depletion of Neural Stem Cells and Impairs Hippocampal Neurogenesis
    Sierra, Amanda; Martín-Suárez, Soraya; Valcárcel-Martín, Roberto; Pascual-Brazo, Jesús; Aelvoet, Sarah-Ann; Abiega, Oihane; Deudero, Juan J.; Brewster, Amy L.; Bernales, Irantzu; Anderson, Anne E.; Baekelandt, Veerle; Maletić-Savatić, Mirjana; Encinas, Juan M.
    Cell Stem Cell (May, 2015) DOI: 10.1016/j.stem.2015.04.003
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