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Nora Bengoa Vergniory

Principal Investigator

Ramón y Cajal Fellow, Ikerbasque Research Fellow

Nora Bengoa Vergniory

Research groups:

Contact

Email:Nora.BV@achucarro.org

Tel.:(+34) 94 601 2095

Science Park UPV/EHU, Sede building
B. Sarriena, s/n
E-48940 Leioa

0000-0002-3700-0464

About me

In 2014 I completed a PhD at the University of the Basque Country which focused on the study of Wnt signaling during early neuronal differentiation in human stem cell models. I then joined the Wade-Martins laboratory at Oxford University to complete my post-doctoral training and pursue my interests in Parkinson’s and Alzheimer’s, and I have since focused on the interplay between aggregation in neurodegeneration. Later, in 2018 I became an Oxford-BMS/Celgene Research Fellow which allowed me to research the role of glia and further investigate the roles of astrocytes and microglia in disease.


I am now a Principal Investigator at Achucarro Basque Center for Neuroscience where my research laboratory continues to investigate the crosstalk between aggregation and glia in the context of disease.

Selected publications:

  • Marc Emmenegger, Dr. Elena De Cecco, […], Dr. Nora Bengoa-Vergniory, […], Dr. Mathias Jucker and Dr. Adriano Aguzzi. LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies. EMBO Molecular Medicine, 2021 Jul 26;e14745.

  • Ryan BJ*, Bengoa-Vergniory N*, […] and Wade-Martins R. Proteomics analysis highlights REST as a potential neuroprotective target for Parkinson’s disease in an alpha synuclein overexpressing BAC-transgenic mouse model. (* equal contribution) Journal of Neuroscience. 2021 Feb 8; JN-RM-1478-20.

  • Nora Bengoa-Vergniory, […] and Javier Alegre-Abarrategui. Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease. Acta Neuropathologica  Communications. 2021 Jan 28;9(1):18.

  • Bradley M. Roberts, […], Nora Bengoa-Vergniory, Richard Wade-Martins, Peter J. Magill and Stephanie J. Cragg. GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model . Nature communications. 2020 11(1):4958.

  • Nora Bengoa-Vergniory, Emilie Faggiani, […] and Richard Wade-Martins. CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and mouse models of Parkinson’s. Nature communications. 2020 11(1):4885.

  • Butkovich LM, […], Bengoa-Vergniory N , Wade-Martins R, Weinshenker D, Tansey MG. Transgenic mice expressing human alpha-synuclein in noradrenergic neurons develop locus coeruleus pathology and non-motor features of Parkinson’s disease. Journal of Neuroscience. 2020 40(39):7559-7576.

  • Carroll Rutherford Fields, Nora Bengoa-Vergniory*, Richard Wade-Martins*. Targeting alpha-synuclein as a therapy for Parkinson’s Disease. (* co-corresponding). Frontiers in Molecular Neuroscience. 2019, 12, 255.

  • Benjamin Henry Mcleod Hunn, Siv Vingill, Sarah Threlfell, Javier Alegre-Abarrategui, Thierry Deltheil, Nora Bengoa-Vergniory, […], Richard Wade-Martins. Impairment of macroautophagy in dopamine neurons has opposing effects on parkinsonian pathology and behaviour. Cell reports. 2019, 29, 4, 920-931.

  • Federico Zambon, Marta Cherubini, Hugo J R Fernandes, Charmaine Lang, Brent J Ryan, Viola Volpato, Nora Bengoa-Vergniory, […], Richard Wade-Martins. Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons. Human molecular genetics . 2019 Jun 15;28(12):2001-2013.

  • Bengoa-Vergniory N, Roberts RF, Wade-Martins R, Alegre-Abarrategui J. Alpha-synuclein oligomers: a new hope. Acta Neuropathologica. 2017 Dec;134(6):819-838.

Publications

  1. Autophagy Deficits Underly Selective Neuronal Vulnerability to Alpha Synuclein Fibrils in Alzheimer’s and Parkinson’s iPSC Derived Neurons
    Abey, Ajantha S; Ng, Bryan; Heon-Roberts, Rachel; Carlyle, Becky C.; Bengoa-Vergniory, Nora; Wade-Martins, Richard
    Alzheimer's & Dementia (Dec, 2024) DOI: 10.1002/alz.087271

  2. Crosstalk between mitochondria–ER contact sites and the apoptotic machinery as a novel health meter
    Larrañaga-SanMiguel, Alvaro; Bengoa-Vergniory, Nora; Flores-Romero, Hector
    Trends in Cell Biology (Oct, 2024) DOI: 10.1016/j.tcb.2024.08.007

  3. BirthSeq, a new method to isolate and analyze dated cells in different vertebrates
    Rueda-Alaña, Eneritz; Grillo, Marco; Vázquez, Enrique; Salas, Sergio Marco; Senovilla-Ganzo, Rodrigo; Escobar, Laura; Quintas, Ana; Benguría, Alberto; Aransay, Ana María; Bengoa-Vergniory, Nora; Dopazo, Ana; Encinas, Juan Manuel; Nilsson, Mats; García-Moreno, Fernando
    Development (Jul, 2024) DOI: 10.1242/dev.202429

  4. Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation
    Do, Quyen B.; Noor, Humaira; Marquez-Gomez, Ricardo; Cramb, Kaitlyn M. L.; Ng, Bryan; Abbey, Ajantha; Ibarra-Aizpurua, Naroa; Caiazza, Maria Claudia; Sharifi, Parnaz; Lang, Charmaine; Beccano-Kelly, Dayne; Baleriola, Jimena; Bengoa-Vergniory, Nora; Wade-Martins, Richard
    npj Parkinson's Disease (Apr, 2024) DOI: 10.1038/s41531-024-00694-2

  5. Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model
    Ciceri, D.; Gregorio-Zabala, L.; Llama-Pino, X.; Kurt, B.; Olano-Bringas, J.; Villegas-Zafra, P.; Bengoa-Vergniory, N.
    Journal of visualized experiments : JoVE (Jun, 2023) DOI: 10.3791/65453

  6. Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons
    Beccano-Kelly, Dayne A.; Cherubini, Marta; Mousba, Yassine; Cramb, Kaitlyn M. L.; Giussani, Stefania; Caiazza, Maria Claudia; Rai, Pavandeep; Vingill, Siv; Bengoa-Vernigory, Nora; Ng, Bryan; Corda, Gabriele; Banerjee, Abhirup; Vowles, Jane; Cowley, Sally; Wade-Martins, Richard
    iScience (Jun, 2023) DOI: 10.1016/j.isci.2023.107044
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