Research Interest

I have devoted my scientific career to deciphering the role of CB ₁ receptors in brain pathophysiology using a variety of experimental approaches that include biochemical and radioligand binding methods, electrophysiology, live cell imaging tecnhiques and rodent models of demyelination, among others. A main objective of my research activity is to evaluate the involvement of CB ₁R populations located in glial cells in the cellular processes that govern white matter damage/repair and determine their usefulness as therapeutic targets in multiple sclerosis (MS). My work in this field has allowed defining the presence and functional significance of CB ₁R in oligodendrocyte populations (Mato et al., Glia 2009; Manterola et al., Front Neuroanat 2022; Sanchez-de-la-Torre et al., Cell Death Dis 2022), the potential of targeting endocannabinoid hydrolysis in MS (Bernal-Chico et al., Glia 2015; Manterola et al., Neuropharmacology 2018) and more recently, the adaptations in endocannabinoid signaling in astrocytes and microglia during autoimmune demyelination (Moreno-García et al., Biomolecules 2020).